2-Chloroisobutyryl chloride, also known as 2-chloro-2-methylbutyryl chloride, has the chemical formula ClC(CH3)2COCl. Its nature, use, formulation and safety information are described below.
Nature:
2-Chloroisobutyryl chloride is a colorless to pale yellow liquid with a pungent odor. It is an acid chloride compound with high reactivity.
Use:
2-chloroisobutyryl chloride is commonly used as a reagent for organic synthesis, such as for drug synthesis, pesticide synthesis, etc. It can be used to prepare compounds such as amides, esters, ketones and acid chlorides.
Preparation Method:
The preparation of 2-chloroisobutyryl chloride can be obtained by reacting 2-isobutyric acid with thionyl chloride. First, 2-isobutyric acid and thionyl chloride are mixed at a low temperature to produce 2-chloroisobutyryl sulfoxide. The product is then reacted with hydrochloric acid to give the final product 2-chloroisobutyryl chloride.
Safety Information:
2-Chloroisobutyryl chloride has a pungent odor and is irritating to the eyes, skin and respiratory tract. During use, attention should be paid to protective measures to avoid inhalation or contact with skin and eyes. In case of accidental contact, please wash with water in time and seek medical help. In addition, 2-chloroisobutyryl chloride should be stored separately from oxidants and strong bases during storage and transportation to avoid dangerous accidents.